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Identification of Two Pentatricopeptide Repeat Genes Required for RNA Editing and Zinc Binding by C-terminal Cytidine Deaminase-like Domains*

Identifieur interne : 000E15 ( Main/Exploration ); précédent : 000E14; suivant : 000E16

Identification of Two Pentatricopeptide Repeat Genes Required for RNA Editing and Zinc Binding by C-terminal Cytidine Deaminase-like Domains*

Auteurs : Michael L. Hayes ; Karolyn Giang ; Beniam Berhane [États-Unis] ; R. Michael Mulligan

Source :

The Journal of Biological Chemistry [ 0021-9258 ] ; 2013.

RBID : PMC:3868764

Abstract

Background: Many pentatricopeptide repeat (PPR) proteins are RNA site specificity factors and include C-terminal DYW deaminase domains.

Results: ELI1 and DOT4 are required for editing single sites. The DYW deaminase domain binds two zinc atoms.

Conclusion: The C terminus of PLS-type PPR proteins shares molecular characteristics with cytidine deaminase.

Significance: This study provides the first evidence that DYW deaminase domains bind zinc.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868764

DOI: 10.1074/jbc.M113.485755
PubMed: 24194514
PubMed Central: 3868764

Affiliations:

Le document en format XML

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<author><name sortKey="Hayes, Michael L" sort="Hayes, Michael L" uniqKey="Hayes M" first="Michael L." last="Hayes">Michael L. Hayes</name>
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<author><name sortKey="Giang, Karolyn" sort="Giang, Karolyn" uniqKey="Giang K" first="Karolyn" last="Giang">Karolyn Giang</name>
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<author><name sortKey="Berhane, Beniam" sort="Berhane, Beniam" uniqKey="Berhane B" first="Beniam" last="Berhane">Beniam Berhane</name>
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<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Californie</region>
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<wicri:cityArea>Chemistry, University of California, Irvine</wicri:cityArea>
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<author><name sortKey="Mulligan, R Michael" sort="Mulligan, R Michael" uniqKey="Mulligan R" first="R. Michael" last="Mulligan">R. Michael Mulligan</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of Two Pentatricopeptide Repeat Genes Required for RNA Editing and Zinc Binding by C-terminal Cytidine Deaminase-like Domains<xref ref-type="fn" rid="FN1">*</xref>
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<author><name sortKey="Berhane, Beniam" sort="Berhane, Beniam" uniqKey="Berhane B" first="Beniam" last="Berhane">Beniam Berhane</name>
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<series><title level="j">The Journal of Biological Chemistry</title>
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<front><div type="abstract" xml:lang="en"><p><bold>Background:</bold>
 Many pentatricopeptide repeat (PPR) proteins are RNA site specificity factors and include C-terminal DYW deaminase domains.</p>
<p><bold>Results:</bold>
 ELI1 and DOT4 are required for editing single sites. The DYW deaminase domain binds two zinc atoms.</p>
<p><bold>Conclusion:</bold>
 The C terminus of PLS-type PPR proteins shares molecular characteristics with cytidine deaminase.</p>
<p><bold>Significance:</bold>
 This study provides the first evidence that DYW deaminase domains bind zinc.</p>
</div>
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<name sortKey="Mulligan, R Michael" sort="Mulligan, R Michael" uniqKey="Mulligan R" first="R. Michael" last="Mulligan">R. Michael Mulligan</name>
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<country name="États-Unis"><region name="Californie"><name sortKey="Berhane, Beniam" sort="Berhane, Beniam" uniqKey="Berhane B" first="Beniam" last="Berhane">Beniam Berhane</name>
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Identification of Two Pentatricopeptide Repeat Genes Required for RNA Editing and Zinc Binding by C-terminal Cytidine Deaminase-like Domains*

Identification of Two Pentatricopeptide Repeat Genes Required for RNA Editing and Zinc Binding by C-terminal Cytidine Deaminase-like Domains*

Source :

Abstract

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